Any investigator working for an Institution with an active Federal Wide Assurance (FWA) on file with the U.S. Department of Health and Human Services (DHHS), Office for Human Research Protections (OHRP). FWA numbers for institutions can be searched for at If an FWA does not exist for a specific institution guidance on requesting an FWA can be found at

Recipients of NBB tissue shall submit a progress report upon publication, completion of the research using the tissue or within one-year of receipt of the tissue. If publication occurs after the initial progress report is submitted to NBB the requestor is expected to follow up with NBB to indicate that a publication is available.

We encourage grant applicants to submit a request with details of your proposed research through NBB. The brain bank directors and NIH staff will review this, and may provide feedback. If evidence of funding is provided and the samples are available, they will be shipped at the requestor's expense. If funding is pending, and the request is approved in principle, the NBB can provide a letter of support if needed.

The only expense the requestor or receiving lab will be expected to cover is the cost for shipping samples. If your tissue request is approved, you will be asked to provide this shipping information.

Authority to sign MTAs on behalf of the RECIPIENT ORGANIZATION is highly variable. In most cases, Principal Investigators and their staff do not have the signatory authority to legally bind their Institution in Material Transfer Agreements. Please ensure that your MTA is signed by the RECIPIENT SCIENTIST as well as the appropriate Authorized Official prior to submitting your tissue request to the NBB. For most academic institutions, the "Authorized Official" will be a representative from the Technology Transfer Office. The "Recipient Scientist" will be the requestor or the Principal Investigator. Please contact the NBB with any further questions.

The MTA is effective for 1 year after it has been electronically countersigned by the NIH Authorized Official. The contact information is available on the MTA template.

The NBB approved/signed MTA will be available via the "Agreements" tab of the request. The requesting institution officials will receive an unsigned copy of the MTA during the e-signature process. It is the responsibility of the Requestor/Investigator to download the NBB signed MTA and provide it to requesting institution officials as necessary.

The NBB standard MTA should be used, as is, unless it is absolutely necessary to make minor changes. In the event that minor changes are required, the website will let you add comments or notes to each section of the MTA during the regular workflow. Please note that adding comments or notes to the standard MTA will lengthen the request process.

 IRB Protocol NumberIRBTitleUniversity of Miami Brain Endowment Bank19920358 (CR0001775)University of Miami Institutional Review BoardBrain Endowment BankUniversity of Maryland Brain and Tissue BankHM-HP-00042077The University of Maryland Institutional Review BoardUniversity of Maryland Brain and Tissue Bank5-58The Maryland Department of Health and Mental Hygiene IRBUniversity of Maryland Brain and Tissue BankHarvard Brain Tissue Resource Center2015P002028Partners Human Research CommitteeBrain Tissue Repository for Research on Neurological and Psychiatric DisordersThe Human Brain and Spinal Fluid Resource Center (managed by Sepulveda Research Corporation)PCC#: 2015-060672
VA Project #: 0002Department of Veterans Affairs – Los AngelesNIH Brain and Tissue Repository - CaliforniaMt. Sinai Brain BankHAR-13-059Bronx VA Medical Center Institutional Review BoardThe NIMH, NICHD, NINDS Brain and Tissue RepositoryBrain Tissue Donation Program at the University of PittsburghREN14120157/IRB981146University of Pittsburgh Institutional Review BoardUniversity of Pittsburgh NIMH, NICHD, NINDS Brain and Tissue Repository

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