As you are all aware, the COVID-19 pandemic is impacting many academic and medical institutions across the country. As a result, the NeuroBioBank is experiencing disruptions to tissue recoveries from potential donors as well as in the distributions of approved specimen requests. Investigators with submitted applications should anticipate delays in shipments. Please send your questions or comments regarding potential delays to the NeuroBioBank (firstname.lastname@example.org). We thank everyone for their continued understanding during this challenging period.
Please note that the NeuroBioBank inventory is refreshed on a regular basis, and should serve as a guide when requesting samples. However, there may be discrepancies between available tissues and samples that have been processed. For the most accurate assessment on all tissue requests, we recommend that requestors include as much information on desired subject and tissue characteristics as possible, and respond to any follow up inquiries when prompted.
The RNA Integrity Number (RIN) values listed should serve as a general quality metric. The actual RIN value may vary due to various factors, including brain regions tested, tissue preservation method, and transport conditions. If needed, we recommend that receiving labs test the RIN value to ensure a sample is appropriate to use in the proposed studies.
We welcome any feedback on improving this service; please contact us.
External Bank Request
Notice: You have selected a specimen that
is held by a repository that is not part of the
NeuroBioBank network. In order to request this
specimen, you must visit the external repository site
to initiate a request. If you continue, your current
specimen search will remain and a new tab in your
browser will open taking you to the external
site. Requests for tissue from repositories that are
not part of the NBB network are governed by the
policies of that repository, and not by those of the
NIH NeuroBioBank. Requests from these sites will be
managed externally and will not be considered part of
your NBB request.
contact us for
instructions on how to request this
Search the NeuroBioBank for Tissue Samples
The NIH NeuroBioBank contains an inventory of specimens that are available through its brain and tissue repository network, as well as some that are offered by external repositories. To select a specimen that is part of the NeuroBioBank network, simply mark the checkbox in the "Add/Remove" column. External specimens are marked with a and can only be obtained by going through the request process of the external repository. Clicking the will prompt you to visit the specimen request page of the associated external repository. When you have selected all desired NIH NeuroBioBank network specimens, click on the "Create Request" button and your checked selections will be automatically added to your request.
Subjects contained within the NBB inventory have undergone extensive neuropathological evaluation and have been characterized using all available donor records (e.g. medical records, autopsy reports, family interviews). In general, diagnoses contained within the NBB inventory are classified based on the International Classification of Diseases (ICD-10) coding schema; however, for conditions that are inadequately represented by this categorization system, the NBB has generated codes and labels that best represent the condition(s) of the subject. The user should be aware that it is not uncommon for a subject to be diagnosed in life with one disorder, only to have the neuropathological evaluation reveal the presence of a different or additional condition(s). The user should consider this when searching / selecting specimens for inclusion in a study.
The following definitions are used to distinguish the types of diagnostic characterization of donors:
Clinical Brain Diagnosis
Psychiatric and neurologic diagnoses made based on the clinical records and case review.
Diagnoses made based on results of a neuropathological exam. Note: The neuropathology diagnosis is distinct from neuropathological findings (e.g. diffuse plaques in frontal lobe, Braak stage). Neuropathological findings are not currently available in the NBB database but are available for each subject upon request.
Diagnoses made based on genetic testing.
Unaffected (Comparison) Control
A subject with the absence of a clinical brain, neuropathology, or genetic diagnosis.
Diagnoses made based on the clinical records and review not primarily affecting the brain but can affect brain function.
Information Regarding Basis of Clinical Brain Diagnosis
Basis of Clinical Brain Diagnosis
As the procedures used to determine clinical brain diagnoses can vary across NBB sites, the level of evidence used to assign a clinical brain diagnosis to a subject is captured within the "Basis of clinical brain diagnosis" field.
Sufficient evidence exists to:
make a clinical diagnosis based on medical history and neuropathological exam or genetic data, or
make a clinical diagnosis by the consensus of expert clinicians, or
Confirm the absence of any brain-related diagnoses (i.e., Unaffected Control).
Diagnosis is based on the clinical impressions of the clinician reviewing the available information, but that information is insufficient to render a confirmed diagnosis.
The available information is insufficient to form a reasonable impression of, or to exclude, any brain-related diagnoses. These cases are used to fill requests for pilot tissue to test out methods using human post-mortem tissue.
Information Regarding De-Identified Age in Subjects Aged 89 and Older
De-Identified Age in Subjects Aged 89 and Older
As subject's age, in combination with other health information, could potentially be a unique identifier for individuals aged 89 and older, these subjects are listed as aged 89+, following HIPAA Privacy Rule.